50 % of patients are asymptomatic but splenomegaly present in > 50 % of cases of CML in the initial chronic phase.
- Diagnosis is based on blood counts and proof of diagnosis is attained by demonstration of philadelphia chromosome, t ( 9;22 ).
The typical clinical course is triphasic:
- Accelerated phase ( 15 - 29 % of blast in blood or BM, more than 20 % basophils in blood, thrombocytosis or thrombocytopenia unrelated to therapy or clonal cytogenetic evolution.
- Blast phase/ blast crisis ( 30 % or more of the blasts in blood and bone marrow ).
The current standard therapy is Imatinib.
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