Multiple Sclerosis

Multiple sclerosis is the chronic inflammatory demyelinating disease of the central nervous system.

Clinical course:

• Relapsing and remitting
• Primary progressive
• Secondary progressive

Management:

Symptomatic Treatment

• Anti-spasmodic agent
• Mild relapse - nil treatment.
• Moderate to severe relapse - high dose methylprednisolone.
• Recent accelerated deterioration of PP/SP MS - high dose methylprednisolone.

Disease modifying agent

• Interferon beta reduces the frequency of relapses in RR - MS by about a third and its severity.
• Glatiramer is useful in case of tolerance to Glatiramer.
• Natlizumab - if interferon beta and Glatiramer are ineffective.
• Mitoxantrone